Model: Hypothalamic cell line

>

 

Project ‘Hypoglycemia And Estrogen’

 

 

 

 

 

Experimental Questions

  1. Does hypoglycemic injury trigger apoptosis in subpopulations of hypothalamic neurons through specific death pathways? Is estrogen able to provide protection against injury?
  2. Is the neuroprotection of estrogen mediated through ERalpha or plasma membrane receptor?
  3. Are there caspase induced neuronal cell death?